Editorial: Drug trial disaster offers a warning

时间:2019-03-02 11:15:01166网络整理admin

TALK about medical disasters and landmark tragedies come to mind: birth defects caused by thalidomide, deaths caused by the painkillers Opren (Oraflex) and Vioxx, and the demise of teenager Jesse Gelsinger during a gene therapy trial. It seems likely we can now add to this list TGN1412, the experimental drug that was given to six healthy young men in the UK last week which sent their immune systems into sudden frenzy (see “One drug, six men, disaster…”). What caused these reactions is still being investigated: was it overdose, contamination or the drug itself?